Figure 2

Visual Representation of Acute (1×) Stress Network. Upper panels: The 1× IMO network is reorganized around Egr1 and Stat3 and their links are grouped in terms of the top enriched functional modules cell cycle, cytokine-cytokine and MAPK. Network edges (black lines) link nodes (proteins/genes represented by open circles). Closest Egr1 network neighbors were calculated within the HUBBA website using Djikstra’s algorithm and were re-displayed with Cytoscape. Lower panel: The rat adrenal medulla 1× IMO full network contains 1717 genes/proteins (nodes) and 6554 interactions (edges) and is organized around Egr1 and Stat3 which are major hubs in this network. Note: upward pointing arrows (Prlh, Chgb, and Atp5b) indicate activation and downward pointing arrows (Egf) indicate suppression of expression.