Figure 2

Illustration of exponential interpolation for the birth-death process with , and N =5×10 ⁴ . Yellow horizontal dotted line is the desired number of successful trajectories, i.e., . Blue and green circles denote the past intermediate biasing parameters for R ₁ and R ₂, respectively, normalized with respect to k ⁽⁰⁾. Blue and green dashed lines are the interpolants constructed from the past intermediate basing parameters, and the red triangles are candidate biasing parameters computed according to Step 3 in Subsection Updating intermediate reaction rates.