Table 1 Metabolites identified as individually statistically significantly different during chemotherapeutic treatment using two-way ANOVA for OCCs and OCSCs

OCC

Control vs IC₅₀ vs 1.5 × IC₅₀

2-Butyl-1-octanol

6.88E-04

1.48E-07

1.96E-07

Hexadecane

2.83E-03

4.81E-11

0.831

D-Glucose

2.83E-03

7.21E-03

1.73E-03

Uracil

4.50E-03

1.05E-11

1.96E-07

L-Tyrosine

6.00E-03

6.35E-08

2.26E-03

Erythronic acid

7.07E-03

6.16E-03

0.424

Xylobiose

0.047

0.140

0.162

Control vs IC₅₀

2-Butyl-1-octanol

0.016

3.03E-06

4.81E-05

Uracil

0.039

4.28E-07

1.53E-04

D-Glucose

0.039

1.07E-03

0.011

Hexadecane

0.041

1.93E-07

0.766

L-Tyrosine

0.041

2.01E-06

1.19E-03

Erythronic acid

0.041

0.089

0.644

Erythritol

0.041

0.281

0.484

Control vs 1.5 × IC₅₀

Uracil

0.025

2.84E-08

3.09E-06

Hexadecane

0.025

3.41E-07

0.510

L-Tyrosine

0.025

1.05E-04

0.013

D-Glucose

0.025

0.041

7.10E-03

Erythronic acid

0.025

0.098

0.496

Ethanolamine

4.82E-03

2.76E-05

1.39E-05