Pathway enrichment of specially existent miRNA — mRNA regulation for each stage along CIN progress. For the Efficient Pairs (EPs) detected by the SIG++ method, the central part in this figure displays the particular existence of miRNA — mRNA regulations along the stages. Each color has its own meaning exhibited visually in the figure and is correspondingly mentioned in the context, such as ‘Green’ referring to the Efficient Pairs with miRNA regulation only existent in normal stage. The left part (i.e. Venn diagram) in this figure shows how to partition the Efficient Pairs into 6 types. The meanings of Set 1 ~ Set 4 are described in Table 3, and their shadow sections in Venn diagram refer to the EPs with regulation particularly existent in certain stage(s), indicated in corresponding colors. Finally, the pathway enrichment of EPs with particularly existent regulation in certain stage(s) are also illustrated in corresponding colors.