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Figure 1 | BMC Systems Biology

Figure 1

From: Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae

Figure 1

Structure of the Sln1-Ypd1-Ssk1 relay and the HOG MAPK pathway. Under normal growth conditions, Sln1 activates Ypd1, which in turn inhibits Ssk1. Increased osmolarity inhibits Sln1, resulting in activation of Ssk1 and of the MAP kinase Hog1 through the upstream MAP3Ks Ssk2 and Ssk22 and the MAP2K Pbs2. Activated Hog1 regulates transcriptional and metabolic changes within the cell that increase production and retention of glycerol.

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BMC Systems Biology

ISSN: 1752-0509

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