Figure 5
From: Iron acquisition and oxidative stress response in aspergillus fumigatus
Model results comparing the application of two hypothetical anti-fungal drugs to treat a simulated A. fumigatus infection. Iron is fixed at low (0) while superoxide is allowed to randomly toggle between low (0) and high (1). (A) Two representative superoxide trajectories. (B) ROS stable distributions for no drug, either drug individually, or both drugs together. Vertical dashed lines represent ROS SDMs. Drug 1 targets siderophore-mediated iron uptake. Drug 2 targets oxidative stress response. Simulations are initialized from the state in row 2 of the low iron, high superoxide block in Figure 2.