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Table 1 Summary of literature search - alcohol addiction

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Author Ethnicity Sample size Phenotype Salient gene(s) Salient SNP(s) Statistical analysis
Batel et al. [47] EA 134 Alcohol dependence DRD1 rs686 P = 0.0008
Bierut et al. [77] EA, AA 5632 Increased aversion from alcohol ADH1B rs1229984 OR = 0.34 P = 6.6E-10
Cao et al. [78] Han Chinese 603 Alcohol addiction 5-HTR rs6313 OR = 0.71 P = 0.001
Chen et al. [79] EA, AA 3627 Alcohol addiction PKNOX2 rs1426153 rs11220015 rs11602925 rs750338 rs12273605 rs10893365 rs10893366 rs12284594 P = 5.75E-5, 6.86E-5, 4.24E-5, 4.26E-5, 3.0E-4, 1.72E-5, 1.37E-5, 1.97E-6
Deb et al. [25] South Asian 144 Alcohol addiction OPRM1 rs1799971 P = 0.02
Desrivieres et al. [80] E 145 Drinking behavior P13K rs2302975 rs1043526 P = 0.0019, 0.0379
Enoch et al. [81] AA 360 Alcohol addiction HTR3B rs1176744 P = 0.002
Ehringer et al. [35] EA, Hisp, AA 108 Alcohol response CHRNB2 rs2072658  
Haller et al. [37] EA, AA 1315 Alcohol addiction CHRNB3 rs149775276 P = 2.6E-4 for EA, P = 0.006 for AA
Hill et al. [82] EA 1000 Alcohol dependence KIAA0040 rs2269650 rs2861158 rs1008459 rs2272785 rs10912899 rs3753555 P = 0.033, 0.037, 0.014, 0.062, 0.035, 0.020
Kalsi et al. [83] EA, AA 847 Alcohol addiction DKK2 rs427983 rs419558 rs399087 P = 0.007
Kumar et al. [26] Bengali/Hindu 310 Alcohol addiction OPRM1 rs16918875 rs702764 rs963549 P = 0.0364
Kuo et al. [84] E 1238 Initial sensitivity to alcohol GAD   P = 0.002
London et al. [85] EA   Risk for alcohol addiction ANKK1 rs1800497 P = 0.001
Mignini et al. [51] E 560 Dopaminergic system; alcohol dependence DRD2/ANKK1 rs1800497 P = 0.023
Munoz et al. [86] E 1533 Number of drinks per day ADH1B, ADH6 rs1229984 in ADH1B rs3857224 in ADH6 rs1229984: OR = 0.19, P = 4.77E-10 for men, OR = 0.48, P = 0.0067 for women; rs38572: OR = 1.61, P = 1.01E-3 for women, NS for men
Novo-Veleiro et al. [87] E 457 Risk for alcohol addiction miR-146a rs2910164 OR = 1.615 P = 0.023
Preuss et al. [88] E (German & Polish) 3091 Alcoholism ADH4 rs1800759 rs1042364 rs1800759: OR = 0.88 rs1042364: OR = 0.87
Ray et al. [89] CA, As, Latino, NA, AA 124 Level of response to alcohol/drinking problems GABRG1 rs1497571 P < 0.01
Samochowiec et al. [90] EA 275 Alcohol dependence MMP-9 rs3918242 P < 0.01
Schumann et al. [91] E 1544 Alcohol dependence NR2A, MGLUR   OR = 2.35, 1.69
Treutlein et al. [92] E 296 Potential alcohol dependence CRHR1   
Wang et al. [42] EA, AA 2309 Alcohol dependence CHRNA5 rs680244 P = 0.003
Wang et al. [93] EA 2010 Alcohol dependence C15orf53 rs12903120 rs12912251 rs12903120: P = 5.45E − 8
Xuei et al. [94] EA 1923 Risk for alcohol addiction GABRR1, GABRR2 rs17504587 rs282129 rs13211104 rs9451191 rs2821211 rs6942204 P = 0.04. 0.03, 0.03, 0.021, 0.025, 0.04
Yang et al. [95] EA, AA 3564 Alcohol dependence HTR3B rs3891484 rs375898 D’ > 7