Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Reyes-Gibby, Cielito C.; Yuan, Christine; Wang, Jian; Yeung, Sai-Ching J.; Shete, Sanjay

doi:10.1186/s12918-015-0167-x

Table 1 Summary of literature search - alcohol addiction

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Author	Ethnicity	Sample size	Phenotype	Salient gene(s)	Salient SNP(s)	Statistical analysis
Batel et al. [47]	EA	134	Alcohol dependence	DRD1	rs686	P = 0.0008
Bierut et al. [77]	EA, AA	5632	Increased aversion from alcohol	ADH1B	rs1229984	OR = 0.34 P = 6.6E-10
Cao et al. [78]	Han Chinese	603	Alcohol addiction	5-HTR	rs6313	OR = 0.71 P = 0.001
Chen et al. [79]	EA, AA	3627	Alcohol addiction	PKNOX2	rs1426153 rs11220015 rs11602925 rs750338 rs12273605 rs10893365 rs10893366 rs12284594	P = 5.75E-5, 6.86E-5, 4.24E-5, 4.26E-5, 3.0E-4, 1.72E-5, 1.37E-5, 1.97E-6
Deb et al. [25]	South Asian	144	Alcohol addiction	OPRM1	rs1799971	P = 0.02
Desrivieres et al. [80]	E	145	Drinking behavior	P13K	rs2302975 rs1043526	P = 0.0019, 0.0379
Enoch et al. [81]	AA	360	Alcohol addiction	HTR3B	rs1176744	P = 0.002
Ehringer et al. [35]	EA, Hisp, AA	108	Alcohol response	CHRNB2	rs2072658
Haller et al. [37]	EA, AA	1315	Alcohol addiction	CHRNB3	rs149775276	P = 2.6E-4 for EA, P = 0.006 for AA
Hill et al. [82]	EA	1000	Alcohol dependence	KIAA0040	rs2269650 rs2861158 rs1008459 rs2272785 rs10912899 rs3753555	P = 0.033, 0.037, 0.014, 0.062, 0.035, 0.020
Kalsi et al. [83]	EA, AA	847	Alcohol addiction	DKK2	rs427983 rs419558 rs399087	P = 0.007
Kumar et al. [26]	Bengali/Hindu	310	Alcohol addiction	OPRM1	rs16918875 rs702764 rs963549	P = 0.0364
Kuo et al. [84]	E	1238	Initial sensitivity to alcohol	GAD		P = 0.002
London et al. [85]	EA		Risk for alcohol addiction	ANKK1	rs1800497	P = 0.001
Mignini et al. [51]	E	560	Dopaminergic system; alcohol dependence	DRD2/ANKK1	rs1800497	P = 0.023
Munoz et al. [86]	E	1533	Number of drinks per day	ADH1B, ADH6	rs1229984 in ADH1B rs3857224 in ADH6	rs1229984: OR = 0.19, P = 4.77E-10 for men, OR = 0.48, P = 0.0067 for women; rs38572: OR = 1.61, P = 1.01E-3 for women, NS for men
Novo-Veleiro et al. [87]	E	457	Risk for alcohol addiction	miR-146a	rs2910164	OR = 1.615 P = 0.023
Preuss et al. [88]	E (German & Polish)	3091	Alcoholism	ADH4	rs1800759 rs1042364	rs1800759: OR = 0.88 rs1042364: OR = 0.87
Ray et al. [89]	CA, As, Latino, NA, AA	124	Level of response to alcohol/drinking problems	GABRG1	rs1497571	P < 0.01
Samochowiec et al. [90]	EA	275	Alcohol dependence	MMP-9	rs3918242	P < 0.01
Schumann et al. [91]	E	1544	Alcohol dependence	NR2A, MGLUR		OR = 2.35, 1.69
Treutlein et al. [92]	E	296	Potential alcohol dependence	CRHR1
Wang et al. [42]	EA, AA	2309	Alcohol dependence	CHRNA5	rs680244	P = 0.003
Wang et al. [93]	EA	2010	Alcohol dependence	C15orf53	rs12903120 rs12912251	rs12903120: P = 5.45E − 8
Xuei et al. [94]	EA	1923	Risk for alcohol addiction	GABRR1, GABRR2	rs17504587 rs282129 rs13211104 rs9451191 rs2821211 rs6942204	P = 0.04. 0.03, 0.03, 0.021, 0.025, 0.04
Yang et al. [95]	EA, AA	3564	Alcohol dependence	HTR3B	rs3891484 rs375898	D’ > 7

Back to article page

ISSN: 1752-0509

Contact us

General enquiries: ORSupport@springernature.com

BMC Systems Biology

Contact us