Fig. 3
Prediction of effect of multiple vaccinations with increasing dosage using the calibrated model. Model predictions were obtained with adenovirus vaccination with a dose of 1×1010 RLU per mm3 (purple lines), a dose of 1×108 RLU per mm3 (green lines), and a dose of 1×106 RLU per mm3 (red lines) every 5 days for a total of 10 times following the initial vaccination with a dose of 1.1×106 RLU per mm3 on day 5 after tumor implantation. a TE1, b TE2, c TE3, d LV, e Total tumor cells (CMHCI+ + CMHCI-), f IFNG, g TNFA, and h TN