Fig. 4
From: Distinguishing the rates of gene activation from phenotypic variations
Illustrations of the energy landscapes and transition paths with fast switching rates. a The global quasi-potential energy landscape of the genetic switching system. The most probable switching paths from off to on state (purple solid curve) and from on to off state (red solid curve) both pass through the saddle point. b Details of subfigure A. c, d The principal curves (green dashed curves) fitted from shading points obtained by Gillespie’s algorithm compare with the optimal transition paths. The result shows good matching between the fitted curves and the theoretical results. The parameters d G =140, k G =2800, k G0=28, and the others are the same with those in Fig. 2