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Fig. 4 | BMC Systems Biology

Fig. 4

From: The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms

Fig. 4

CCKR modular map and PathExpand interactors. a The CCKR map modules are connected by ‘activation’ and ‘inhibition’ relationships (indicated by black lines with a pointed arrow and red lines with a bar-headed arrow, respectively) and comprise i) receptor-centered modules CCK1R, CCK2R and EGFR, ii) modules common to CCK1R and CCK2R (PKC, SRC, MAP3K11, MAPK1/3, RAF1, AKT1, NFκB, MAP3K11, Rho GTPase, FAK1/2), iii) CCK1R-specific modules NOS1 and PKA, and iv) CCK2R-specific modules BCL and β-catenin. Color-coding depicts published experimentally documented information concerning involvement of the module-encoded signaling mechanisms in gastrin-mediated regulation of cellular responses proliferation, migration and apoptosis. b PathExpand interactors (full names, see Table 3) shown for seven of the 18 modules (excluding transcription factor- centered modules)

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BMC Systems Biology

ISSN: 1752-0509

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