Table 4 Hypothetical effects of the targets’ drugs on treatment of sperm-egg interaction defects
Protein name | Role in sperm-egg interaction | Expression level/infertile vs fertile | Hypothetical role of drugs | Drug name/effect | Suggest for further study on sperm-egg interaction |
|---|---|---|---|---|---|
FN1 | Interact with α5β1 in sperm and oocyte | ↑ [37] | ↑ FN1 may defect sperm-egg interaction | Ocriplasmin/↓ | √ |
EGFR | Interact with ZP3 | ↑ in breast cancer and there is a relationship between breast cancer and infertility [48] | ↑ EGFR may defect sperm-egg interaction | Cetuximab, Panitumumab, Gefitinib, erlotinib hydrochloride/ ↓ | √ |
COL1A1 | Interact with β1 in sperm and oocyte | × | Induces the binding sperm-egg interaction | Collagenase clostridium histolyticum/ pull apart | × |
ITGAV, ITGB3, ITGB5 | Facilitates interaction between sperm and egg | ↑ in breast cancer [55] and there is a relationship between breast cancer and infertility [48] | ↑ ITGAV, ITGB3, ITGB5 may defect sperm-egg interaction | Cilengitide/↓ | √ |