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Table 1 Features of different enzyme kinetic parameter estimation methods. “WLS” stands for the weighted least squares method. “TLS” stands for the total least squares method. “Raaijmakers” is the maximum likelihood method of Raaijmakers

From: Towards in vivo estimation of reaction kinetics using high-throughput metabolomics data: a maximum likelihood approach

  Multiple substrates/ Reversible Relative Error in all
  products reaction error variables
Double reciprocal
Direct linear
WLS
TLS
Raaijmakers
InVEst