Fig. 4
From: Mining for novel candidate clock genes in the circadian regulatory network
Phase regulation of circadian transcripts. a The distribution of the expression phase of genes that are significantly circadian in different tissues (FDRJTK<0.05) [33] classified according to the combinations of transcription factors (TFs) binding their promoter based on ChIP-seq data. E-box: BMAL1 or NPAS2 or CLOCK, D-box: E4BP4, RRE: REV-ERB α or REV-ERB β or ROR α. The grey vertical lines represent the median phase of expression within each group of transcripts and the line width increases with increasing significance of the mean-direction (Rayleigh test). The number of transcripts in each group is also provided. b The estimated distribution of phases for each combination of TFs from the generalized linear model fit of the transcript phases to the normalized scores for each TF group within the ChIP-seq data in our meta-analysis. Under the model, the phase of expression within each group is assumed to follow a von Mises distribution, whose mean is linearly dependent on the normalized scores (see “Method” section)