Fig. 5
From: Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis
Relative cell positions at sprout tips. Enlarged view of a sprout tip in a simulation of (a) the contact inhibition model and of (b) the cell elongation model. WT tip cells are colored red, Vegfr2 haploid tip cells dark purple and Vegfr2 stalk cells light purple. The leader cells of the sprouts are marked with yellow stars. The leader cell is the contact inhibition model has relatively little cell-cell contact compared to other cells in the sprout, while the leader cell in the cell elongation model is in contact with other cells for a large part of its membrane due to the multi-cellular composition of the sprout tip