Reconstruction of gene networks using prior knowledge

BMC Systems Biology

Table 2 Comparison of MEN, BBSR and PriorPC in terms of AUROC

	DREAM4	E. coli	B.subtilis	Using TS
MEN_low	0.908	0.768	0.828	Yes
MEN_high	0.912	0.776	0.842	Yes
BBSR_low	0.872	0.675	0.791	Yes
BBSR_high	0.86	0.719	0.793	Yes
PriorPC (α=1)	0.887	0.753	0.835	No
PriorPC (α=0.75)	0.885	0.71	0.801	No

For all three methods, 50 % of the edges present in the gold standard network were randomly selected and assigned a true prior (1 for MEN and BBSR, a random probability in (0.5,1] for PriorPC). For PriorPC, α is given in brackets. MEN and BBSR also use time-series(TS) data. Results are comparable across the three algorithms

ISSN: 1752-0509