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Fig. 10 | BMC Systems Biology

Fig. 10

From: Tracing regulatory routes in metabolism using generalised supply-demand analysis

Fig. 10

Rate characteristic plots of the reaction blocks of threonine in the aspartate metabolism model. a The fluxes of the demand blocks 10 and 11, and the supply block 9 of Thr. b The rate characteristic plot of the Thr-supply block 9 with partial and total response coefficients indicated as lines intersecting the J 9-curve at the steady-state value of Thr. Partial response coefficients (solid lines) indicate the relative contribution of each respective route of interaction of Thr with reaction block 9 towards the total response coefficient (dashed line). Note that \(\protect \phantom {\dot {i}\!}{{~\!\!}^{v_{9}}R^{J_{9}}_{\textit {Thr}}}\), \(\protect \phantom {\dot {i}\!}{{~\!\!}^{v_{10}}R^{J_{9}}_{\textit {Thr}}}\) and \(\protect \phantom {\dot {i}\!}{{~\!\!}^{v_{11}}R^{J_{9}}_{\textit {Thr}}}\) were omitted due to their zero contributions towards \(\protect \phantom {\dot {i}\!}{R^{J_{9}}_{\textit {Thr}}}\). The unlabelled dashed curve in both (a) and (b) represents the total demand and the steady-state value of Thr is indicated as a vertical dotted line (see Table 2)

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