Fig. 5
Example for illustration of module effect. Nodes represent diseases with OMIM numbers, modules with index numbers, proteins with OMIM numbers and domains with Pfam numbers. Edges connecting two nodes represent a known association. Nodes with the same background colors represent 7 known associations between corresponding diseases and proteins. (i) Disease OMIM # corresponds to disease/trait names as: [179800]: RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL DOMINANT. [179830]: RENAL TUBULAR ACIDOSIS, PROXIMAL. [267200]: RENAL TUBULAR ACIDOSIS III. [267300]: RENAL TUBULAR ACIDOSIS, DISTAL, WITH PROGRESSIVE NERVE DEAFNESS. [602722]: RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE; RTADR. [604278]: RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION. [259730]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 3; OPTB3. [259700]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 1; OPTB1. [259710]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 2; OPTB2. [259720]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 5; OPTB5. [600329]: OSTEOPETROSIS AND INFANTILE NEUROAXONAL DYSTROPHY. [611490]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4; OPTB4. [611497]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 6; OPTB6. [612301]: OSTEOPETROSIS, AUTOSOMAL RECESSIVE 7; OPTB7. (ii) Protein OMIM # corresponds to gene name as: [164360]: ATP5A1; [114815]: CA8; [109270]: SLC4A1; [192132]: ATP6V1B1; [603345]: SLC4A4; [611492]: CA2; [602642]: TNFSF11; [153440]: LTA; [191160]: TNF; [300386]: CD40LG; [146690]: IMPDH1; [602727]: CLCN7; [602743]: PRKAG2; [604592]: TCIRG1; [611716]: ATP6V0A2. (iii) Domain Pfam # corresponds to domain name as: [PF00006]: ATP-synt_ab; [PF02874]: ATP-synt_ab_N; [PF00194]: Carb_anhydrase; [PF00955]: HCO3_cotransp; [PF07565]: Band_3_cyto; [PF00306]: ATP-synt_ab_C; [PF00229]: TNF; [PF00478]: IMPDH; [PF00571]: CBS; [PF00654]: Voltage_CLC; [PF01496]: V_ATPase_I