Skip to main content

Table 6 Summary statistics on the toxicity and UnBiological values for different biological endpoints

From: Low potency toxins reveal dense interaction networks in metabolism

Endpoint Number Correlation with Toxicity Endpoint distribution (log molar) Ub5 distribution Ub6 distribution
   Ub5 Ub6 mean median Std. dev skew max min mean median St. Dev skew max min mean median St. Dev. skew max min
Trout 24 h 186 -0.230 ** -0.337 *** -5.73 -5.64 1.39 -0.14 -0.99 -10.04 7.58 7 1.92 0.01 11 2 8.94 9 1.91 -0.74 12 2
Trout 96 h 181 -0.419 *** -0.516 *** -5.73 -5.78 1.77 0.76 -0.23 -10.88 7.58 7 1.94 0.01 11 2 8.94 9 1.92 -0.76 12 2
Pteronarcys (24 h) 52 -0.433 ** -0.385 ** -6.25 -6.83 1.27 0.75 -3.24 -7.98 8.52 8 1.70 0.15 11 6 9.71 10 1.60 -0.37 12 6
Pteronarcys (96 h) 52 -0.456 *** -0.369 ** -7.08 -7.58 1.44 0.61 -3.71 -9.55 8.44 8 1.67 0.22 11 6 9.65 10 1.58 -0.29 12 6
Bluegill (24 h) 157 -0.149 -0.215 ** -5.71 -5.63 1.41 -0.21 -2.31 -9.61 7.92 8 1.82 0.22 11 4 9.30 9 1.65 -0.28 12 4
Bluegill (96 h) 172 -0.216 ** -0.276 *** -5.88 -5.84 1.48 -0.16 -2.31 -10.20 7.85 8 1.82 0.23 11 4 9.23 9 1.70 -0.33 12 4
Gammarus (24 h) 113 -0.437 *** -0.208 * -6.17 -6.35 1.46 -0.16 -3.52 -10.73 8.19 8 1.71 0.43 11 6 9.64 10 1.46 -0.16 12 6
Gammarus (96 h) 132 -0.407 *** -0.205 * -6.56 -6.66 1.63 -0.12 -3.20 -10.82 8.14 8 1.71 0.46 11 6 9.57 9 1.47 -0.12 12 6
Fathead minnow 578 -0.311 *** -0.308 *** -3.83 -3.82 1.38 -0.15 -0.04 -9.38 5.59 5 1.41 1.07 11 2 7.07 7 1.75 0.19 12 2
Rat oral 814 -0.441 *** -0.372 *** -2.40 -2.27 0.91 -0.99 -0.43 -6.98 6.57 6 1.64 0.40 11 2 8.11 9 2.14 -0.34 12 2
Mouse oral 398 -0.199 *** -0.191 *** -2.56 -2.47 0.82 -1.30 -0.65 -6.34 6.96 7 1.43 -0.02 11 2 8.80 9 1.86 -0.57 12 2
Rat IP 170 -0.214 ** -0.147 -3.03 -2.88 0.86 -0.66 -0.90 -5.61 6.85 7 1.35 0.24 11 3 8.64 9 1.71 -0.31 12 3
Mouse IP 290 -0.180 ** -0.161 ** -3.21 -3.02 1.04 -0.93 -0.99 -7.50 6.85 7 1.45 -0.09 11 2 8.50 9 1.98 -0.46 12 2
AMES 163 -0.316 *** -0.518 *** -4.72 -4.25 1.67 -0.51 -1.52 -9.88 6.33 7 1.33 0.07 11 2 8.40 9 2.09 -0.49 12 2
CPDBAS rat 519 -0.198 *** -0.191 *** -4.18 -4.19 1.42 -0.24 -0.47 -9.85 6.36 6 1.35 -0.09 11 2 8.03 8 2.08 -0.23 12 2
CPDBAS mouse 402 -0.145 ** -0.198 *** -3.62 -3.54 1.18 -0.60 -0.53 -9.32 6.19 6 1.43 -0.18 10 2 7.85 8 2.21 -0.32 12 2
CPDBAS hamster 44 -0.430 ** -0.351 * -4.46 -4.53 0.99 0.43 -1.89 -6.05 5.95 6 1.51 -0.64 9 2 7.32 8 2.43 -0.17 12 2
Drosophila 139 -0.397 *** -0.337 *** -1.43 -1.29 0.94 -0.82 0.23 -4.80 5.82 6 1.35 0.17 10 2 7.32 7 2.07 0.00 12 2
Lemna - non-Herbicides 149 -0.428 *** -0.502 *** -4.85 -5.12 1.47 0.85 -0.24 -8.20 7.01 7 1.50 -0.37 11 2 8.68 9 1.94 -0.87 12 2
Lemna - Herbicides 174 -0.392 *** -0.428 *** -6.21 -6.08 1.65 -0.19 -2.99 -10.23 8.02 8 1.63 0.27 11 4 9.56 9 1.77 -0.02 12 4
Tetrahymena 334 -0.408 *** -0.448 *** -3.51 -3.59 0.97 0.10 -1.07 -5.82 5.62 5.5 1.03 -0.01 8 2 7.16 7 1.55 -0.11 12 2
Chlorella 91 -0.578 *** -0.738 *** -2.86 -3.16 1.47 0.43 1.06 -6.10 6.15 6 1.74 0.86 11 2 7.62 7 1.77 -0.43 11 2
Scenedesmus 63 -0.237 -0.467 *** -5.80 -5.90 1.61 1.24 0.10 -8.04 6.27 6 1.15 0.10 9 3 8.17 9 1.53 -0.92 11 3
Yeast 253 0.095 -0.014 -4.69 -4.56 0.44 -0.61 -4.01 -5.77 6.76 7 1.02 0.01 10 4 8.96 9 1.42 -0.01 12 5
NCI 768 -0.113 ** -0.137 *** -5.03 -4.67 1.38 -1.19 -2.03 -10.02 7.04 7 1.07 0.81 11 4 9.14 9 1.33 -0.20 12 5
HERG 229 -0.062 0.179 ** -5.50 -5.42 1.27 -0.09 -2.36 -8.59 7.14 7 1.01 -0.14 10 4 9.67 9 1.29 -0.03 12 5
Oestrogenic 131 -0.024 -0.342 *** -5.62 -5.32 1.78 -0.47 -2.52 -9.65 6.16 6 0.95 0.49 10 4 8.97 9 1.24 -0.06 12 6
Tadpole narcosis 141 -0.043 -0.267 ** -2.47 -2.37 1.15 -0.32 -0.19 -5.33 5.01 5 1.32 0.82 10 2 6.16 6 1.82 0.48 11 2
COX-2 107 -0.069 -0.149 -6.36 -6.52 1.51 0.48 -3.00 -8.70 7.72 8 0.56 0.36 10 7 9.20 9 0.68 -0.08 11 8
Antihistamine 61 -0.097 -0.0126 -7.99 -8.13 1.27 0.84 -4.05 -10.59 6.92 7 0.76 0.61 9 6 10.2 10 1.26 -0.23 12 7
  1. Left column, biological endpoints correlated in this study. Column 2 – number of molecules in the data set for that endpoint. Columns 3 and 4, correlation of the endpoint with UnBiological measures Ub5 and Ub6, as per Table 3. The rest of the table lists summary statistics on the toxicity endpoints (all in Moles/lirte for solution studies, moles/kg for animal studies), Ub5 or Ub6. Listed are mean, median, Standard deviation (St. Dev.), Skew (a measure of the asymmetry of the data - positive skewness indicates a distribution with an asymmetric tail extending toward more positive values, negative skewness indicates a distribution with an asymmetric tail extending toward more negative values), and maximum (max) and minimum (min) values
  2. The maximum and minimum values in each column are underlined for ease of comparison. There are more minimum values for the biological endpoint in the pharmacologically defined endpoints Cox-2 and antihistamine, as would be expected as these molecules have been selected specifically for pharmacological potency (i.e. for low EC50 values). The molecular set used for Tadpole Narcosis has more minimum values for Ub5 and Ub6 statistics than might be expected by chance, suggesting that the set of molecules tested for narcosis induction in tadpoles is biased with respect to the other sets used in this study. Other sets are generally not obviously different from each other, and specifically the Ub5 and Ub6 statistics for HERG, Oestrogenic potential. COX-2 inhibition and Antihistamine efficacy appear be broadly similar to the Ub5 and Ub6 statistics for the molecule sets analysed for toxicity endpoints