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Fig. 4 | BMC Systems Biology

Fig. 4

From: Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation

Fig. 4

Model results suggest that IGFBP can suppress phosphorylation of IGF1R for specific quantitative combinations. a Treatment with IGF2 in the presence of OVCAR5-secreted IGFBPs resulted in significantly lower levels of pIGF1R, data replotted from Figs. 1c and 2a. b Model results demonstrated that IGFBP would suppress pIGF1R by 7 % when available at 100-fold the level of IGF1R. OVCAR5 levels of IGFBPs were 540-fold the level of IGF1R, and were predicted to substantially decrease pIGF1R. c IGF2-induced proliferation was significantly decreased in the presence of IGFBPs secreted by OVCAR5 cells. d IGF2-induced proliferation of OVCAR5 cells was significantly decreased in the presence of recombinant IGFBP3, * indicates p < 0.05

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BMC Systems Biology

ISSN: 1752-0509

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