Table 2 (Semi-) Quantitative information extracted from literature used for the calibration of the model

1.a

  hyper-pRb domination in BCP-ALL cells

qualitative

1.b

  hypo-pRb positive BCP-ALL cells

16 % (±13.2 %)

1.c

  hypo-pRb detection threshold

3000 (molecules/cell)

2.a

  Cycling cells

94 %

2.b

  Quiescent cells

2 %

2.c

  Apoptotic cells

4 %

2.d

  Cycling cells in S/G2/M phases

10 %

2.e

  Cycling cells in G1 phase

84 %

2.f

  Cycling cells in early-G1

13.7 %

3.a

  Mean Cell cycle duration of BCP-ALL cells (T _c )

112.5 h (±46.8 h)^a

3.b

  S-phase duration in BCP-ALL cells (T _s )

18 h

3.c

  G2-phase duration

6 h

3.d

  M-phase duration

1 h

3.e

  Mean G1-phase duration in BCP-ALL cells

87.5 h (±46.8 h)

  Estimated realistic time-range for G1/S transition in BCP-ALL

~2400 - ~8000 min

3.f.

  early-G1 phase duration in BCP-ALL cells

~800 min

3.g.

  S-phase midpoint

9 h after G1/S transition

4.a

  S-phase passage levels

300 (molecules/cell)

4.b

  Levels (rate) before activating modifier activation

<150 (molecules/cell) (<=0 ((molecules/cell)/min))

4.c

  Levels after activating modifier activation

<300 (molecules/cell)

4.d

  Levels at the midpoint of S-phase

470 (molecules/cell)

  Maximum difference between the initial and the instant levels

500 (molecules/cell)