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Table 7 Definition of calibration penalties related to pRb Levels

From: Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

hypo-pRb Levels
\( \begin{array}{l} hypo-pR{b}_{penalt{y}_i}={{\displaystyle \sum_{Time=0}^{Time= SimulationTime} hypo-pRb}}_{instantpenalt{y}_i}\\ {}\kern13em i=0,1,2,3,4\end{array} \) \( hypo-pR{b}_{instant\ penalt{y}_0}=\left\{\begin{array}{c}\hfill hypo-pRb< hypo-pRb\ detection\ levels,\kern0.5em Fla{g}_0\hfill \\ {}\hfill 0\hfill \end{array}\right. \)
\( hypo-pR{b}_{instant\ penalt{y}_1}=\left\{\begin{array}{c}\hfill hypo-pRb\ge hypo-pRb\ detection\ levels,\kern0.5em Fla{g}_1\hfill \\ {}\hfill 0\hfill \end{array}\right. \)
\( hypo-pR{b}_{instant\ penalt{y}_2}=\left\{\begin{array}{c}\hfill hypo-pRb\ge hypo-pRb\ detection\ levels,\kern0.5em Fla{g}_2\hfill \\ {}\hfill 0\hfill \end{array}\right. \)
\( hypo-pR{b}_{instant\ penalt{y}_3}=\left\{\begin{array}{c}\hfill hypo-pRb\ge hypo-pRb\ detection\ levels,\kern0.5em Fla{g}_3\hfill \\ {}\hfill 0\hfill \end{array}\right. \)
\( hypo-pR{b}_{instant\ penalt{y}_4}=\left\{\begin{array}{c}\hfill hypo-pRb\ge hypo-pRb\ detection\ levels,\kern0.5em Fla{g}_4\hfill \\ {}\hfill 0\hfill \end{array}\right. \)
\( hypo-pR{b}_{penalt{y}_{sum}}={\displaystyle \sum_i} hypo-pR{b}_{penalt{y}_i},\ i=0,1,2,3,4 \)
(pRb + hypo-pRb) vs. hyper-pRb (all forms) levels
\( \begin{array}{l}\left(pRb+ hypo-pRb\right)\;vs.\; hyper-pR{b}_{penalt{y}_i}={\displaystyle \sum_{Time=0}^{Time= SimulationTime}\left(pRb+ hypo-pRb\right)}\;vs.\; hyper-pR{b}_{instantpenalt{y}_i}\\ {}\kern32.5em i=0,1\end{array} \) \( \left(pRb+ hypo-pRb\right)vs.\ hyper-pR{b}_{instant\ penalt{y}_0}=\left\{\begin{array}{c}\hfill hyper-pRb\ \left( all\ forms\right)>pRb+ hypo-pRb, \kern0.5em 0\hfill \\ {}\hfill Pre\_ Modifier\hfill \end{array}\right. \)
\( \left(pRb+ hypo-pRb\right)vs.\ hyper-pR{b}_{instant\ penalt{y}_1}=\left\{\begin{array}{c}\hfill hyper-pRb\ \left( all\ forms\right)>pRb+ hypo-pRb, \kern0.5em 0\hfill \\ {}\hfill Post\_ Modifier\hfill \end{array}\right. \)