Fig. 5

Signalling network downstream of TNF α and EGF in human colon carcinoma cells. a The model for the merged TNF α and EGF pathways. Node colours represent the activity level of the corresponding modelled reactants at time t=15 min after a stimulation of 100 ng/ml TNF α + 100 ng/ml EGF. b Modelled production of IL-1 α after stimulation with 100 ng/ml TGF α (24 h). c Modelled activation of JNK1 and MK2 after stimulation with 5 ng/ml TNF α + 10 μg/ml C225 (2 hours). The _data suffix identifies experimental data; all other series are computed by ANIMO