Fig. 2
From: Cross-species Conservation of context-specific networks
Components of the CroCo framework. The CroCo framework consists of a data repository (croco-repo), an Application Programming Interface (API) (croco-api), an interactive web interface (croco-web), and a Cytoscape plug-in (croco-cyto). The croco-repo is a central database, which includes derived context-specific and global networks, ortholog mappings, and gene annotations. Via the croco-web interface, networks can be compared based on several properties such as the number of total interactions, or the number of in-/out-interactions (in-/out-degree) of specific genes. For Cytoscape, we developed a plug-in (croco-cyto) for downstream analysis. Finally, in order to assist the development of customized workflows, the croco-api can be used to integrate CroCo in additional processing and analysis pipelines