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Table 6 Example sentences with PK DDI from literature

From: Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature

PMID Study type Sentence with DDI
10193676 in vivo Both erythromycin and itraconazole increased the area under the lignocaine plasma concentration-time curve [AUC(0-infinity)] and lignocaine peak concentrations by 40-70 % (P<0.05).
10923859 in vitro Rifalazil-25-deacetylation in microsomes was completely inhibited by diisopropyl fluorophosphate, diethyl p-nitrophenyl phosphate and eserine, but not by p-chloromercuribenzoate or 5,5′-dithio-bis(2-nitrobenzoic acid), indicating that the enzyme responsible for the rifalazil-25-deacetylation is a B-esterase.
  1. The drug names involved in a PK DDI relation in each example are bolded