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Table 8 Semantic class description for literature of PK DDI

From: Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature

Semantic class Definition Example
Drug Drugs, metabolites quinidine
Enzyme CYP450 enzymes CYP1A2
PK parameter PK Parameters AUC
Number Dose, sample size, values of PK parameters 40–70 %
Mechanism Trigger words related to DDI mechanisms stimulate
Change Change of PK parameters decrease
Degree Severity of PK parameter change strongly
Negation Negative expression negligible