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Fig. 6 | BMC Systems Biology

Fig. 6

From: Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy

Fig. 6

Differentiation potential simulated using the CLE model with a wide range of intrinsic and extrinsic noise strengths. The combined intrinsic and extrinsic noise strength in the range of 10-3 to 10-1 was examined. a The differentiation potential of CT-treated glioma cells. b The differentiation potential of glioma cells treated with CT combined with inhibition of cyclin D1 feedback. The results were evaluated at 48 h. The inhibition of cyclin D1 feedback was simulated by increasing the value of the Michaelis constant (K 6a ) of the cyclin D1 feedback loop by 10-fold in the CLE model

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