Fig. 4
From: How time delay and network design shape response patterns in biochemical negative feedback systems
Amplitude/period curves of the p53 model under variation of τ. The analysis is performed for the p53 model (3) without and with synthetically activated (ν=2, κ=1.23; ν=3, κ=1.73) auto-inhibitory feedback using values of the Hill coefficient n=3 and n=5 (fitted value) of the DNF function S 2. Period and amplitude were quantified for the time delay τ varied in the range from 1 to 8 hours with the step 0.2 hour. Both amplitude and period of oscillations increase with τ