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Table 2 Control nodes for the reduced T-LGL network

From: Identification of control targets in Boolean molecular network models via computational algebra

Solution

Control targets

Attractor

Basin size

\(u^{+}_{8}=1\)

Ceramide=ON

0000000100000001

100 %

\(u^{+}_{9}=1\)

DISC=ON

0000000010000001

100 %

\(u^{+}_{10}=1\)

Caspase=ON

0000000001000001

100 %

\(u^{+}_{12}=1\)

BID=ON

0000000000010001

100 %

\(u^{-}_{14}=1\)

MCL1=OFF

0000000000000001

100 %

\(u^{-}_{15}=1\)

S1P=OFF

0000000000000001

100 %

\(u^{+}_{6}=1\)

Fas=ON

0000010000000001

100 %

\(u^{-}_{11}=1\)

FLIP=OFF

  

\(u^{-}_{7}=1\)

sFas=OFF

0000000000000001

100 %

\(u^{-}_{11}=1\)

FLIP=OFF

  
  1. The last two rows represent combinatorial actions of two nodes. All attractors are steady states, and the basin sizes include the steady states themselves. Notice that node x 16=Apoptosis is a conceptual node in this model, thus it is not a relevant solution for network control