Table 1 The minimal sets of control nodes for the reverse control
From: Attractor landscape analysis of colorectal tumorigenesis and its reversion
APC mutation | APC + KRAS mutations | APC + KRAS + PTEN mutations | APC + KRAS + PTEN + TP53 mutations | Control direction |
|---|---|---|---|---|
Control nodes for a quiescent phenotype | ||||
beta-catenin | beta-catenin | beta-catenin | beta-catenin |
|
P115RhoGEF | P115RhoGEF | P115RhoGEF | P115RhoGEF |
|
MEK | MEK | MEK | MEK |
|
PP2A | PP2A | PP2A | PP2A |
|
Control nodes for a normal proliferative phenotype | Â | |||
beta-arrestin | beta-arrestin | beta-arrestin | beta-arrestin |
|
Erk | Erk | Erk | Erk |
|
P115RhoGEF | P115RhoGEF | P115RhoGEF | P115RhoGEF |
|
Smad2/4 | Smad2/4 | Smad2/4 | Smad2/4 |
|
| Â | Â | Â | Snail |
|
