Fig. 5

Highest co-expression of DEGs in specific brain regions. a Interconnectedness of transcriptional coexpression networks at various developmental stages and in different brain regions based on DEGs or randomly selected genes were evaluated using RNA-seq data from the BrainSpan Atlas. A pair of genes was defined as coexpressed if their expression correlation coefficient |R| was ≥ 0.9, across all tissues from a given brain region and a given developmental stage (Table 1). Dotted lines indicate numbers of connections (i.e., edges) in networks actually observed for DEGs, while the histograms represent distributions of the numbers of edges in 10,000 simulated networks derived from randomly picked genes. b Multiple testing adjusted –log10(P-value) for the significance of difference between the numbers of observed and simulated network edges