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Table 3 DEGs or 22q11.2 genes with the most co-expressed genes in different brain regions*

From: Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion

Brain Region

Embryonic

Adolescence

DEGs

22q11.2

DEGs

22q11.2

FC

KIAA1467

CDC45

HERC3

CRKL

MAPKAPK3

COMT

DDX3X

PRODH

CHD1L

TXNRD2

MTMR7

DGCR6

SEPT2

SLC25A1

ELL2

LZTR1

RFXANK

THAP7-AS1

LRRTM3

C22orf29

SC

SCAF11

CDC45

PJA2

C22orf39

KHNYN

SLC25A1

ZMYM2

MED15

MAPKAPK3

CLDN5

DPP8

PRODH

TP53

COMT

PDCD6IP

HIRA

LAMC3

CRKL

B4GALT6

TANGO2

SM

PLIN3

CDC45

PDCD6IP

COMT

FGFR2

CRKL

HDAC7

DGCR6

RREB1

THAP7-AS1

UBE3C

CRKL

MAPKAPK3

COMT

LRFN5

PRODH

MCAM

SEPT5

GLRB

SLC25A1

TP

FGFR2

SLC25A1

MEF2A

COMT

MAP7D3

CDC45

NRXN1

DGCR6

PLIN3

RANBP1

FBXO45

CRKL

MAPKAPK3

SCARF2

PDCD6IP

PRODH

TP53

SNAP29

MTMR7

SLC25A1

Total

MAPKAPK3

CDC45

PDCD6IP

PRODH

PLIN3

SLC25A1

MTMR7

DGCR6

SCAF11

COMT

GLRB

COMT

  1. *In each stage and region, DEGs or 22q11 deleted genes were ranked according to their numbers of connection with other DEGs. The top three genes in the “Total” had the highest numbers of connections summed over all four regions in the embryonic or adolescence stages