Table 1 ΔB _ct values of NaV1.7 mutations associated to IEM, SFN and PEPD

IEM

I136V

=H _Φ O

VSD (S1;D_I)

0.12

[12, 58, 69]

S211P

Polar → H _Φ O

VSD (S4;D_I)

-1.09

[70]

F216S

H _Φ O → polar

VSD (S4;D_I)

-1.71

[11, 57]

L823R

H _Φ O → charged

VSD (S4;D_II)

1.23

[7, 71]

W1538R

H _Φ O → charged

VSD (S2-S3;D_IV)

0.18

[72]

I234T

H _Φ O → polar

S4-S5 (D_I)

2.33

[73]

S241T

=Polar

S4-S5 (D_I)

0.34

[23, 74, 75]

I848T

H _Φ O → polar

S4-S5 (D_II)

-5.83

[4, 9, 17, 47, 59]

L858H

H _Φ O → charged

S4-S5 (D_II)

-1.85

[4, 9, 17]

L858F

=H _Φ O

S4-S5 (D_II)

-1.74

[5, 11, 76]

G856D^a

H _Φ O → charged

S4-S5 (D_II)

-0.55

[19]

A863P

=H _Φ O

S4-S5 (D_II)

-0.32

[6]

P1308L

=H _Φ O

S4-S5 (D_III)

0.04

[21]

V1316A

=H _Φ O

S4-S5 (DI_III)

0.36

[47, 77]

A1632E^b

H _Φ O → charged

S4-S5 (D_IV)

0.27

[78]

N395K

polar → charged

Pore (S6;D_I)

5.32

[11, 79]

V400M

=H _Φ O

Pore (S6;D_I)

-0.68

[23, 80]

V872G

=H _Φ O

Pore (S5;D_I)

-2.48

[81]

F1449V

=H _Φ O

Pore (S6;D_III)

-0.51

[10, 23]

A1746G

=H _Φ O

Pore (S6;D_IV)

1.40

[72]

SFN

R185H

=charged

VSD (S2-S3;D_I)

0

[18]

I228M

=H _Φ O

VSD (S4;D_I)

2.04

[18, 82]

I739V

=H _Φ O

VSD (S1;D_II)

0.54

[18, 83]

M1532I

=H _Φ O

VSD (S2-S3;D_IV)

0.15

[18]

M932L

=H _Φ O

Loop Pore (D_II)

0.46

[18]

PEPD

V1298D

H _Φ O → charged

S4-S5 (D_III)

-0.81

[14]

V1298F

=H _Φ O

S4-S5 (D_III)

-0.004

[14, 15, 21]

V1299F

=H _Φ O

S4-S5 (D_III)

0.07

[14, 15, 17]

G1607R

H _Φ O → charged

S4-S5 (D_III)

0.62

[84]

M1627K

H _Φ O → charged

S4-S5 (D_IV)

1.22

[14, 16, 17, 85]