Fig. 3

Visualization of Module 1 with maximized active score S _A detected by the proposed algorithm in network 1. Node color and border are set the same as Fig. 2. Module contains the majority of red nodes that are connected densely, indicating high activity. Notice that compared to small separated modules identified by jActiveModule shown in Fig. 2, this module tends to connect small areas of red nods by including linkage nodes with white or light green color. Although these intermediate nodes shows only modest changes in expression, they serve as bridges for cross-talk between functional groups, or as transcription factors that regulate other genes