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Fig. 3 | BMC Systems Biology

Fig. 3

From: Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

Fig. 3

Model structure of the MAPK module. a Reaction scheme of the MAPK module. Upon addition of growth factors, Raf, MEK and ERK are successively activated in a phosphorylation cascade. Different feedback topologies are assumed to shape context dependent ERK response: Effective negative feedback from ERK to Raf upon EGF stimulation (dotted line from ppERK to dephosphorylation of pRaf), and positive feedback in case of NGF stimulation (dashed line from ppERK to phosphorylation of Raf). b Differential equation model of the MAPK cascade. Bold parameters are the unknown constants, collected in the parameter vector θ, while gray parameters define the specific experimental condition for the simulation

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