Fig. 5

MSM approximation error for the MISA motif. Relaxation of the system from a particular initial configuration (see text), as obtained from a the full transition matrix, b brute force SSA simulation, and c the reduced transition matrix obtained from the MSM. Color-coding is according to the macrostates, as in Figs. 1, 2 and 3: blue, black, red, green correspond to A/B expression phenotypes Hi/Lo, Hi/Hi, Lo/Hi, and Lo/Lo, respectively. d Calculated approximation error as a function of time, comparing the reduced MSM to the full CME dynamics. Network parameter values are same as Figs. 1 and 2