Table 2 Description of the parameter values

V _IFN

Maximum activation rate of the IFN pathway

[ 2.8,11.2]

6.135

(Molecules/Cell) ^∗min

n

Hill coefficient

-

2

Dimensionless

k _IFN

Saturation constant for the IFN pathway

[ 0.0022,0.0088]

0.0055

Molecules/Cell

k _dIFN

Decay rate of the IFN pathway

[ 0.0232,0.0926]

0.0492

min^-1

k _{I S G F3}

Constant for ISGF3 production

[ 0.00012,0.00048]

0.0003

min^-1

k _{d I S G F3}

Decay rate of the ISGF3

[ 0.00068,0.00272]

0.0017

min^-1

k _on

Promoter activation

[ 184.55,738.2]

522.59

min^-1

k _{a I3}

Constant of promoter activation by IFN

[ 7681.6,30727]

22687.02

Molecules/Cell

k _{a I7}

Constant of promoter activation by IRF7

[ 13399,53597]

35281.99

Molecules/Cell

k _off

Promoter inactivation

[ 0.00044,0.00176]

0.0013

min^-1

k _Active

IRF7 transcription rate by active promoter

[ 0.5402,2.161]

1.144

min^-1

^a k _Basal

IRF7 basal transcription rate

[ 0.0312,0.125]

0.0861

min^-1

^b k _dmRNA

Decay rate of mRNA

[ 0.029,0.116]

0.0715

min^-1

^c k _{I R F7}

Translation rate of IRF7

[ 14,56]

43.867

min^-1

k _{d I R F7}

Rate of IRF7 phosphorylation

[ 1.540,6.160]

3.877

min^-1

k _{I R F7d i m e r}

Rate of IRF7 dimerization

[ 0.235,0.94]

0.602

(Cell/Molecules)/min

k _{d I R F7d i m e r}

Decay rate of IRF7 dimers

[ 0.209,0.836]

0.439

min^-1

φ

Scaling factor

-

1

Cell/Molecules