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Table 2 Description of the parameter values

From: A new efficient approach to fit stochastic models on the basis of high-throughput experimental data using a model of IRF7 gene expression as case study

Name Description Range Nominal Units
V IFN Maximum activation rate of the IFN pathway [ 2.8,11.2] 6.135 (Molecules/Cell) min
n Hill coefficient - 2 Dimensionless
k IFN Saturation constant for the IFN pathway [ 0.0022,0.0088] 0.0055 Molecules/Cell
k dIFN Decay rate of the IFN pathway [ 0.0232,0.0926] 0.0492 min-1
k I S G F3 Constant for ISGF3 production [ 0.00012,0.00048] 0.0003 min-1
k d I S G F3 Decay rate of the ISGF3 [ 0.00068,0.00272] 0.0017 min-1
k on Promoter activation [ 184.55,738.2] 522.59 min-1
k a I3 Constant of promoter activation by IFN [ 7681.6,30727] 22687.02 Molecules/Cell
k a I7 Constant of promoter activation by IRF7 [ 13399,53597] 35281.99 Molecules/Cell
k off Promoter inactivation [ 0.00044,0.00176] 0.0013 min-1
k Active IRF7 transcription rate by active promoter [ 0.5402,2.161] 1.144 min-1
a k Basal IRF7 basal transcription rate [ 0.0312,0.125] 0.0861 min-1
b k dmRNA Decay rate of mRNA [ 0.029,0.116] 0.0715 min-1
c k I R F7 Translation rate of IRF7 [ 14,56] 43.867 min-1
k d I R F7 Rate of IRF7 phosphorylation [ 1.540,6.160] 3.877 min-1
k I R F7d i m e r Rate of IRF7 dimerization [ 0.235,0.94] 0.602 (Cell/Molecules)/min
k d I R F7d i m e r Decay rate of IRF7 dimers [ 0.209,0.836] 0.439 min-1
φ Scaling factor - 1 Cell/Molecules
  1. a k Basal was calculated to be at least one order of magnitude smaller than k Active
  2. bDegradation rates for the mRNA were calculated assuming a mRNA half-life in the order of minutes [50]
  3. cBased on the average translation rate in NIH3T3 cells [49]