Skip to main content

Table 1 Parameters of the model

From: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Symbol Name Units LB Initial value UB
v G,max Maximum glucose uptake rate mmol/g DCW ·h 0 2.5 10
K G Half saturation constant for glucose uptake g/L 0 10−4 10−3
v EtOH,B Ethanol minimum secretion rate (batch) mmol/g DCW ·h 0 0.5 3
v Pyr,B Pyruvate minimum secretion rate (batch) mmol/g DCW ·h 0 0.1 2
v Arab,B Arabitol minimum secretion rate (batch) mmol/g DCW ·h 0 0.2 2
v Cit,B Citrate minimum consumption rate (batch) mmol/g DCW ·h 0 0 2
v EtOH,FB Ethanol minimum consumption rate (fed-batch) mmol/g DCW ·h 0 0 2
v Pyr,FB Pyruvate minimum consumption rate (fed-batch) mmol/g DCW ·h 0 0 2
v Arab,FB Arabitol minimum consumption rate (fed-batch) mmol/g DCW ·h 0 0 2
v Cit,FB Citrate minimum consumption rate (fed-batch) mmol/g DCW ·h 0 0 2
α B Sub-optimal growth coefficient (batch) [−] 0 0 10−3
α FB Sub-optimal growth coefficient (fed-batch) [−] 0 0 10−3
m ATP Non-growth associated ATP mmol/g DCW ·h 0 2 10
T Fed Time when secondary metabolite consumption starts in fed-batch cultures h 20 25 32