Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

BMC Systems Biology

Table 2 Values at which problematic parameters were fixed in the cross-calibration stage

Parameter	Fixation value	Units	Reference
v _G,max	6	mmol/g _DCW ·h	[63]
K _G	0.0027	g/L	[63]
v _EtOH,B	0	mmol/g _DCW ·h	-
v _Pyr,B	0	mmol/g _DCW ·h	-
v _Arab,B	0	mmol/g _DCW ·h	-
v _Cit,B	0	mmol/g _DCW ·h	-
v _EtOH,FB	1.21	mmol/g _DCW ·h	*
v _Pyr,FB	0.14	mmol/g _DCW ·h	*
v _Arab,FB	0.15	mmol/g _DCW ·h	*
v _Cit,FB	0.008	mmol/g _DCW ·h	*
α _B	0	[−]	[85]
α _FB	0	[−]	[85]
m _ATP	2.18	mmol/g _DCW ·h	[43]
T _Fed	22	h	*

Parameters marked with ‘-’ in the reference column indicate that no a priori value was assumed for that particular parameter, which is the case for the batch minimum secretion rates. ‘*’ means that the value of a particular parameter was fixed at the mean value achieved in the calibrations, because no information about them could be found in the literature

ISSN: 1752-0509