Table 2 Bimodal Proteins, their functional annotation and their correlation to cell fate. Annotation is based on Genecards [http://www.genecards.org/]
From: Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor
Protein name | Description | Bimodal correlation to death | P-value |
|---|---|---|---|
APAF1 | initiates apoptosis | Increase correlates with death | 3E-13 |
BAG1 | blocks apoptosis, enhances anti-apoptotic effects of BCL2, Inhibits chaperone activity | 8E-07 | |
BAG2 | BCL2-associated, Inhibits chaperones, apoptosis | 2E-03 | |
CACYBP | ubiquitin degradation, beta-catenin degradation, positive regulation of DNA replication | 3E-08 | |
CALM2 | regulates the centrosome cycle and cytokinesis | 3E-04 | |
CKS2 | CDC28 protein kinase, down regulated by p53, G1/S phase transition | 2E-05 | |
IL3RA | interleukin 3 receptor, Immune response IL-3, Apoptosis, Jak-STAT signaling pathway | 5E-49 | |
RAB11A | RAS oncogene, membrane delivery during cytokinesis, protein transport, endocytosis | 2E-08 | |
RBX1 | E3 ubiquitin ligase, cell cycle progression, DNA repair | 2E-02 | |
STK24 | serine/threonine kinase, apoptosis, upstream (MAPK) cascade | 2E-02 | |
STMN1 | destabilizing microtubules, mitotic spindle organization, activated by ERK | 7E-15 | |
TXN | Upregulate JUN & NFkB, apoptosis | 8E-27 | |
DDX5 | RNA helicases, splicing, cellular growth and division, P53 TF | Increase correlates with survival | 1E-05 |
MAP2K2 | kinase, Activates the ERK1 and ERK2, Proliferation, transformation | 2E-05 | |
RFC1 | replication & repair factor, subunit DNA polymerase, S phase of mitotic cell cycle | 9E-08 | |
TBCA | tubulin folding, stabilizing beta-tubulin | 2E-02 | |
H2AFV | H2A histone protein, nucleosome assembly | no correlation with death | 5E-04 |
LMNA | nuclear membrane fibrous, apoptosis, During mitosis disassembled, nuclear stability | 5E-58 | |
PAK2 | p21 activated kinase, cytoskeleton reorganization, anti apoptosis | 2E-10 | |
PCMTD2 | protein modification, protein-L-isoaspartate(D-aspartate)O-methyltransferase domain | 7E-04 | |
PLEC1 | intermediate filaments with MT & microfilaments, apoptosis, cell junction assembly | 1E-04 | |
PRKAR2A | kinase, cAMP-dependent, lipid&glucose metabolism, signaling of GPCR, anti apoptosis | 9E-05 | |
PTPN11 | Phosphatase, an upstream activator of Src & ras, Proliferation, transformation | 1E-02 | |
SPCS1 | proteolysis, metabolic process, removes signal peptides from proteins in the ER | 3E-19 | |
TJP1 | tight junction protein, apoptosis | 2E-02 |