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Table 2 Bimodal Proteins, their functional annotation and their correlation to cell fate. Annotation is based on Genecards [http://www.genecards.org/]

From: Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

Protein name Description Bimodal correlation to death P-value
APAF1 initiates apoptosis Increase correlates with death 3E-13
BAG1 blocks apoptosis, enhances anti-apoptotic effects of BCL2, Inhibits chaperone activity 8E-07
BAG2 BCL2-associated, Inhibits chaperones, apoptosis 2E-03
CACYBP ubiquitin degradation, beta-catenin degradation, positive regulation of DNA replication 3E-08
CALM2 regulates the centrosome cycle and cytokinesis 3E-04
CKS2 CDC28 protein kinase, down regulated by p53, G1/S phase transition 2E-05
IL3RA interleukin 3 receptor, Immune response IL-3, Apoptosis, Jak-STAT signaling pathway 5E-49
RAB11A RAS oncogene, membrane delivery during cytokinesis, protein transport, endocytosis 2E-08
RBX1 E3 ubiquitin ligase, cell cycle progression, DNA repair 2E-02
STK24 serine/threonine kinase, apoptosis, upstream (MAPK) cascade 2E-02
STMN1 destabilizing microtubules, mitotic spindle organization, activated by ERK 7E-15
TXN Upregulate JUN & NFkB, apoptosis 8E-27
DDX5 RNA helicases, splicing, cellular growth and division, P53 TF Increase correlates with survival 1E-05
MAP2K2 kinase, Activates the ERK1 and ERK2, Proliferation, transformation 2E-05
RFC1 replication & repair factor, subunit DNA polymerase, S phase of mitotic cell cycle 9E-08
TBCA tubulin folding, stabilizing beta-tubulin 2E-02
H2AFV H2A histone protein, nucleosome assembly no correlation with death 5E-04
LMNA nuclear membrane fibrous, apoptosis, During mitosis disassembled, nuclear stability 5E-58
PAK2 p21 activated kinase, cytoskeleton reorganization, anti apoptosis 2E-10
PCMTD2 protein modification, protein-L-isoaspartate(D-aspartate)O-methyltransferase domain 7E-04
PLEC1 intermediate filaments with MT & microfilaments, apoptosis, cell junction assembly 1E-04
PRKAR2A kinase, cAMP-dependent, lipid&glucose metabolism, signaling of GPCR, anti apoptosis 9E-05
PTPN11 Phosphatase, an upstream activator of Src & ras, Proliferation, transformation 1E-02
SPCS1 proteolysis, metabolic process, removes signal peptides from proteins in the ER 3E-19
TJP1 tight junction protein, apoptosis 2E-02