Fig. 3

Simulation of the calibrated model (#6 in Table 2) against the experimental data of ⁵⁹Fe injection in mice under iron-deficient diet. The dotted line represents the simulation when only the diet was adjusted, the bold line is the model simulation when both diet and hepcidin synthesis rate were adjusted. Filled circles represent the data from [23] (vertical bars represent one standard deviation). The abscissa represents the proportion of total injected ⁵⁹Fe, the ordinate is time after injection. a plasma, (b) duodenum, (c) bone marrow, (d) red blood cells, (e) liver, (f) spleen, (g) rest of body, and (h) excreted. Note that the standard deviation in panel a is smaller than the size of the symbols, while in panels (g) and (h) it was not indicated as it is very large because these data are algebraic sums of various term