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Fig. 3 | BMC Systems Biology

Fig. 3

From: An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia

Fig. 3

3D Simulation Plots of the MB231 with Different Stem Cell and CCR5+ Populations. a Lower stem cell populations and higher CCR5+ percentages lead to more fingering morphologies. The plots are at day 100. b The top tumor is a cross section of a tumor for simulation with 2% stem cells and 13% CCR5+ cells, with an inset. The bottom tumor is a cross section of a tumor for simulation with 34% stem cells and 13% CCR5+ cells, with an inset. With lower stem cell initial percentages, the tumor is made up of clusters of cells whereas the higher stem cell percentages result in a single larger tumor. Progenitor cells are shown in blue, CCR5+ cells in green, stem cells in red and both CCR5+ and stem cells in yellow

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BMC Systems Biology

ISSN: 1752-0509

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