Hybrid method to solve HP model on 3D lattice and to probe protein stability upon amino acid mutations

BMC Systems Biology

Table 13 Single amino acid mutation of sequences with 27 amino acids

Sequence ID	H-H	mass number	UC number	H	P	P →H	H →P
A ₈	4	9	4	6	21	19	4
A ₃	8	7	2	9	18	17	8
A ₅	8	8	7	9	18	12	8
A ₁₀	11	17	7	11	16	9	11
A ₄	15	13	10	14	13	3	14

H-H is the number of H-H pairs of original sequence. The same continuous amino acids were taken as a mass. Mass number is for original sequence. UC number is the number of mutational amino acid which does not change the H-H interactions. H (P) is the number of hydrophobic (hydrophilic) amino acids in the original sequence. P →H (H →P) is the number of mutational hydrophilic (hydrophobic) amino acid which affected the H-H interactions

ISSN: 1752-0509