Fig. 1
From: MD-Miner: a network-based approach for personalized drug repositioning
Method Overview. There are three modules: Module 1): Construction of mechanism of action (MoA) signaling network (MoAnet) of drug instances (the same drug treatment on different cell lines with different doses and time); Module 2): Construction of patient-specific disease signaling network (Pnet); and Module 3): Scoring of drug sensitivity. For each drug, the average network overlapping nodes between MoAnet and Pnet are calculated and used as the drug sensitivity score for individual patients, and then drugs are ranked based on the sensitivity score in the decreasing order. The top-ranked drugs have higher possibility to be effectively repositioned for given individual patients