Skip to main content

Table 1 The top 15 identified drug-pathway association pairs on CCLE data set to L2,1-iPaD and iPaD methods

From: Identifying drug-pathway association pairs based on L2,1-integrative penalized matrix decomposition

Drug KEGG pathway L 2, 1-iPaD iPaD Validated?
Sorafenib Calcium signaling pathway 0 5.79E-04 Yes
Panobinostat Pancreatic cancer 0 6.07E-04 No
LBW242 Chronic myeloid leukemia 2.80E-44 1.34E-10 No
Nutlin-3 Chronic myeloid leukemia 1.74E-43 4.82E-16 Yes
L-685458 Chronic myeloid leukemia 4.33E-43 3.20E-31 No
17-AAG Chronic myeloid leukemia 9.46E-43 2.79E-20 No
AZD0530 Colorectal cancer 1.62E-41 3.05E-07 No
PD-0332991 Chronic myeloid leukemia 6.93E-41 1.38E-09 Yes
PHA-665752 Chronic myeloid leukemia 1.09E-40 1.97E-20 No
Paclitaxel Chronic myeloid leukemia 2.14E-38 2.52E-16 No
AZD0530 Chronic myeloid leukemia 7.12E-38 5.12E-13 Yes
ZD-6474 Chronic myeloid leukemia 1.62E-21 1.23E-11 No
AZD0530 ErbB signaling pathway 4.41E-16 2.81E-05 Yes
RAF265 ECM-receptor interaction 1.26E-15 0 No
Erlotinib Chronic myeloid leukemia 5.69E-15 1.98E-11 Yes
  1. The superior results are in italic type