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Table 5 The top 20 identified drug-pathway association pairs on NCI-60 data set to L2,1-iPaD and iPaD methods

From: Identifying drug-pathway association pairs based on L2,1-integrative penalized matrix decomposition

Drug KEGG pathway L 2, 1-iPaD iPaD Validated?
Hydroxyurea Neuroactive ligand-receptor interation 0 NAN No
Rebeccamycin T cell receptor signaling pathway 4.12E-16 4.65E-10 Yes
Tiazofurin Cell cycle 8.19E-11 7.54E-07 Yes
Selenazofurin Cell cycle 1.75E-10 2.78E-07 Yes
Mycophenolic Acid Cell cycle 2.61E-10 2.52E-06 No
Lucanthone Tight junction 1.04E-08 4.31E-06 Yes
Tanespimycin Jak-STAT signaling pathway 9.95E-07 2.67E-04 No
Primaquine Natural killer cell mediated cytotoxicity 1.14E-06 2.69E-04 No
Aminoglutethi-mide Primary immunodeficiency 1.30E-06 1.16E-04 No
Geldanamycin Gap junction 7.89E-06 1.87E-04 No
Diallyl Disulfide Acute myeloid leukemia 8.13E-06 8.41E-05 No
Carmustine Cell cycle 8.68E-06 4.58E-04 No
Lomustine Tight junction 1.06E-05 2.64E-04 Yes
Bleomycin Focal adhesion 1.17E-05 4.56E-04 No
Vitamin K 3 Metabolism of xenobiotics by cytochrome P450 2.22E-05 2.71E-04 No
Melphalan T cell receptor signaling pathway 2.64E-05 6.16E-04 Yes
Tegafur Gap junction 6.73E-05 5.60E-04 No
Chloroquine Phosphate Tight junction 7.12E-05 8.76E-04 Yes
Aclacinomyci- ns One carbon pool by folate 1.03E-04 5.41E-04 No
Tamoxifen Pyrimidine metabolism 1.12E-04 1.92E-03 No
  1. The superior results are in italic type