From: Inferring gene regulatory networks from single-cell data: a mechanistic approach
1 | Single-gene, discrete [29] | ||
â—‡ All molecules are discrete | |||
◇mRNA distribution: Beta-Poisson | ↓ | Abundant species treated continuously | |
2 | Single-gene, PDMP (1) | ||
â—‡ Only the promoter is discrete | |||
◇ mRNA distribution: Beta | ↓ | Introduction of interactions via k on, k off | |
3 | |||
â—‡ Both accurate and fast to simulate | |||
◇mRNA distribution: unknown | ↓ | Timescale separation of Protein/mRNA (d 0≫d 1) | |
4 | Simplified network (7) | ||
â—‡ mRNA is removed from the network | |||
â—‡ Conditional mRNA distribution: Beta (8) |