Fig. 2
From: Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection
Metabolic adaptation of the pfkA-mutant of Mtb during shifts in glucose and oxygen concentration. Phases in the phenotypic phase plane (PhPP) are associated with hypothetical scenarios of nutrient availability inside granulomas. a 3D top view of the PhPP diagram while optimizing for growth. The line of optimality (LO) corresponds to the optimal relation between the two metabolic fluxes to obtain maximal Mtb growth. b 2D top view of the PhPP highlighting phases and isoclines. Black dots correspond to the substrate uptake rates used to simulate the metabolic flux distribution characterizing a given phase. The dotted lines depict constant substrate uptake rates kept from one phenotype to another. c Types of granulomas and nutritional environments experienced during Mtb infection