Fig. 4
From: Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection
Metabolic adaptation of the icl-mutant of Mtb during shifts in propionate and oxygen concentration. Phases in the phenotypic phase plane are associated with hypothetical scenarios of nutrient availability inside granulomas. Black dots correspond to the substrate uptake rates used to simulate the metabolic flux distribution characterizing a given phase. The dotted lines depict constant substrate uptake rates kept between one phenotype to another. a 3D top view of the PhPP diagram while optimizing for growth. b 2D top view of PhPP highlighting phases and isoclines. c Types of granulomas and nutritional environments experienced during Mtb infection