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Fig. 1 | BMC Systems Biology

Fig. 1

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

Fig. 1

Flowchart of the analyses performed in this study. The experimentally verified PTM sites were acquired from dbPTM. Since drug binding sites and protein-protein interaction sites were extracted from protein structural information, we mapped all experimentally confirmed PTM sites to known 3D structures in the PDB by using UniProtKB ID and sequence identity. Then, the PTM sites were cross-matched with drug binding sites and PPI contacting sites for the identification of PTM sites associated with drug binding and PPI. Finally, these data were integrated with a PTM structural analytical method and computing programs for building up a web-based system

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BMC Systems Biology

ISSN: 1752-0509

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