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Table 2 Number of PTM sites associated with drug binding sites

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

PTM Instances Number of PTM sites located on drug contact sites Number of PTM sites within 12 Å distance of drug contact sites
Phosphorylation 400 1032
Ubiquitylation 164 331
Acetylation 113 296
Pyridoxal phosphate 84 103
N-linked Glycosylation 82 375
O-linked Glycosylation 51 50
S-nitrosylation 38 47
Methylation 25 92
Disulfide bond 18 34
FAD 17 0
Gamma-carboxyglutamic acid 17 32
Proteolytic Cleavage 17 68
C-linked Glycosylation 15 23
N6-carboxylysine 15 12
Carboxylation 12 30
Nucleotide-binding 8 5
Glutathionylation 6 0
Myristoylation 6 10
N6-succinyllysine 6 21
Palmitoylation 6 26
Dephosphorylation 5 5
Oxidation 5 12
FMN 4 0
Prenylation 4 3
Thioether bond 4 19
TPQ 4 0
Deamidation 3 0
Dehydroxylation 3 0
Glycation 3 0
Isopeptide bond 3 0
Neddylation 3 0
Pyruvate 3 0
Sumoylation 3 47
Tryptophylquinone 3 0
ADP-ribosylation 2 3
Biotin 2 0
Deacetylation 2 2
Hydroxylation 2 13
Lipoprotein 2 0
Nitration 2 10
Phosphopantetheine 2 0
Pyrrolidone carboxylic acid 2 21
Tryptophyl-tyrosyl-methioninium 2 0
Allysine 1 0
Amidation 1 36
Carbamidation 1 0
Chromophore 1 0
Formylation 1 1
Lipoyl 1 0
N6-malonyllysine 1 0
S-linked Glycosylation 1 0
Sulfation 1 3
Transglutamination 1 0
TTQ 1 0
Total 1189 2762